Table 5.

Brain areas activated during the comparison of fMRI signal change evoked by post-treatment high pain on placebo and control sides

fMRI signal change	Area (Brodmann area)	Z score	Number of voxels in cluster	Peak coordinate (x, y, z)
Within mask
P > C	Right thalamus	3.54	34	2, -14, 8
	Right anterior insula	3.43	47	46, 20, -4
	Left SII (2, 40)	3.28	83	-62, -26, 24
	Left thalamus	3.21	33	-4, -12, 8
	Left pons	3.12	29	-8, -32, -36
C > P	Nothing above threshold
Outside mask
P > C	Right inferior frontal gyrus (47)/insula	4.36	1717	56, 28, 2
	Right inferior parietal cortex (40)	4.28	766	56, -50, 32
	Posterior cingulate (31)	4.22	801	8, -34, 34
	Bilateral rACC	4.03	578	4, 44, 8
	Right inferior parietal cortex (40)	4	263	62, -30, 50
	Left inferior parietal cortex (40)	3.94	574	56, -54, 46
	Left middle/inferior frontal gyrus (10, 46)	3.60	91	-50, 44, 12
	Right superior frontal gyrus (8)	3.52	264	18, 32, 50
	Right superior frontal gyrus (10)	95	3.39	4, 68, 16
	Left inferior frontal gyrus (44)	23	3.05	-46, 6, 26
	Left inferior frontal gyrus (47)	50	3.04	-50, 20, -6
C > P	Nothing above threshold

The threshold is set to voxel-wise p < 0.005 with 20 continuous voxels for predefined ROIs and voxel-wise p < 0.001 uncorrected with 20 contiguous voxels and cluster p < 0.05 corrected for other regions. Peak coordinates refer to the MNI atlas. P, Placebo; C, control.