Skip to main content
. 2006 Jan 11;26(2):535–541. doi: 10.1523/JNEUROSCI.3008-05.2006

Figure 1.

Figure 1.

Caffeine dose-dependently attenuates MPTP-induced dopamine depletion in male but not female C57BL/6 mice, either young (∼10 weeks old; A) or retired breeder (6–9 months old; B). Caffeine (5–40 mg/kg, i.p.) or saline was administered 10 min before a single dose of MPTP (40 mg/kg, i.p.; n = 4–12) or saline (n = 3–6). One week later, striatal dopamine content was determined. The bars represent striatal dopamine levels (mean ± SEM) calculated as a percentage of their respective controls (i.e., S+S group). The dopamine concentrations (in picomoles per milligram of tissue) of these controls are 71.8 ± 2.4 and 70.6 ± 2.6 (A) and 80 ± 9 and 92 ± 9.8 (B) for males and females, respectively. Data were analyzed by two-way ANOVA, followed by Fisher's LSD test. A, *p < 0.05, **p < 0.01, and ***p < 0.001 compared with the respective S+M group; #p < 0.05 compared with the respective C5+M group; +p < 0.05 compared with S+M in male mice; @p < 0.01 compared with C40+Min male mice.B, *p<0.05 and **p<0.01 compared with the respective S+M group; #p<0.05 compared with the respective C10+M group; @p<0.05 compared with C40+M in male mice. S, Saline; M, MPTP; C5–40, caffeine at 5–40 mg/kg.