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. 2006 Sep 20;26(38):9794–9804. doi: 10.1523/JNEUROSCI.2116-06.2006

Figure 1.

Figure 1.

Wlds modestly delayed the onset and attenuated the behavioral deficits of EAE. A, Behavioral scores (mean ± SEM) of EAE in C57BL/6 or Wlds mice. Differences between these groups were significant as determined by two-tailed Student's t test, p < 0.05 from 6 d p.i. B, Clinical features of EAE in C57BL/6 or Wlds mice. The onset was significantly delayed in Wlds mice when compared with the wild-type group (*p < 0.01; Student's t test). C, NAD levels (presented as mean ± SEM) of the cervical spinal cords of EAE animals as analyzed by HPLC. In C57BL/6 mice, NAD levels at 2 or 4 weeks p.i. were significantly decreased compared with uninduced controls (p = 0.0012, p = 0.0004 at 2 and 4 weeks p.i., respectively). However, the NAD levels in Wlds mice were preserved compared with those from wild-type EAE mice (**p < 0.001, *p < 0.01 at 2 and 4 weeks p.i., respectively; Student's t test).