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. 2006 Sep 20;26(38):9794–9804. doi: 10.1523/JNEUROSCI.2116-06.2006

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Copyright © 2006 Society for Neuroscience 0270-6474/06/269794-11$15.00/0

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Figure 8. — NAm attenuates neurotoxicity induced by LPS-activated microglia. A, Representative images showing cocultures of E18 cortical neurons and LPS-activated microglia in different conditions stained with Tuj-1 antibody or Hoechst 33258. Images of cultured neurons without microglia (first row), with microglia (second row), with microglia plus 25 mm NAm (third row), and with microglia plus 25 mm NAm (pretreatment only) (fourth row). Scale bar, 100 μm. B, Quantification of Tuj-1-positively stained neurons under different conditions. NAm treatments (both continuous or pretreatment alone) significantly preserved neurons cocultured with LPS-activated microglia (*p < 0.001; Student's t test). Error bars indicate SEM.