Skip to main content
. 2006 Sep 27;26(39):9923–9934. doi: 10.1523/JNEUROSCI.1580-06.2006

Figure 2.

Figure 2.

Phasic charge transfer of EPSCs and IPSCs during CCh-induced oscillations. A, Camera lucida drawing of a PC (i), perisomatic-targeting interneuron (a putative axo-axonic cell; ii), dendritic-targeting interneuron (radiatum-lacunosum moleculare cell; iii), and interneuron-selective interneuron (iv). SR, Stratum radiatum; SP, stratum pyramidale; SO, stratum oriens; SLM, stratum lacunosum-moleculare. B, Bidirectional bandpass-filtered field potential (10–45 Hz; top trace) and EPSCs (bottom trace) recorded from the soma of the cells illustrated in A, at a holding potential of −60 mV. C, Bidirectional bandpass-filtered field potential (10–45 Hz; top trace) and IPSCs (bottom trace) recorded from the same cells at 0 mV (i), +20 mV (ii), and +10 mV (iii, iv). The horizontal solid line is the calculated baseline used for phasic charge estimation (see Materials and Methods). D, The phasic excitatory charge (Qe) differed significantly between cell classes (p < 0.01). PCs, n = 17; perisomatic-targeting interneurons, n = 9; dendritic-targeting interneurons, n = 7; interneuron-selective interneurons, n = 7. E, Phasic excitatory to inhibitory charge ratio (Qe/Qi) in different cell classes. Qe/Qi was smaller in PCs than in all classes of interneuron. PCs, n = 17; perisomatic-targeting interneurons, n = 7; dendritic-targeting interneurons, n = 7; interneuron-selective interneurons, n = 4. F, PCs received a significantly larger phasic inhibitory charge (Qi) than perisomatic-targeting interneurons and dendritic-targeting interneurons. The number of cells is as in E. Error bars indicate SEM. *p < 0.05; **p < 0.01. Scale bars, 100 μm. PTI, Perisomatic-targeting interneuron; DTI, dendritic-targeting interneuron; ISI, interneuron-selective interneuron.