Figure 6.

BIC-sensitive tonic current and NO711-evoked currents measured in CGCs from +/+ and α1^−/− slices maintained in extracellular solution containing 500 nm GABA. A, Current amplitude distributions of 2.5 s segments of current traces devoid of synaptic currents from one +/+ (black fit) and one α1^−/− (gray fit) CGC during application of NO711 (5 μm). The mean baseline current immediately preceding NO711 application was adjusted to 0 in both cases. Gaussian fits of these distributions give mean peak amplitude values of −27.7 ± 0.06 pA for +/+ and −11 ± 0.13 pA for α1^−/−. B, No significant differences between genotypes were observed during application of 25 μm BIC. Application of NO711 elicited an average of 86% larger (p < 0.01) currents in the +/+ than in the α1^−/− neurons (for current values, see Results).