Figure 1.

Epileptiform-like activity triggered in hippocampal slices by removing extracellular Mg²⁺ and by blocking GABA_A receptors. A–E, Extracellular (A, D) and patch-clamp (B, E) recordings in the CA3 region showing ictal-like (A, B) and interictal-like (D, E) events triggered by bath application of 0 Mg²⁺ ACSF and 50–100 μm picrotoxin. C, F, Average values of event duration (left) and frequency (right) for ictal-like events (C; n = 344 events from 35 experiments) and interictal-like events (F; n = 274 events from 9 experiments).