Figure 5.

Ca entry into presynaptic terminals during NMDAR activation triggers I-LTP. A, mIPSCs before and after application of NMDA/glycine. B, Plot of percentage change in mean mIPSC frequency versus time (n = 12 without CPP; n = 6 with CPP). C, Plot of percentage change in mean mIPSC amplitude versus time (n = 12; except for the first two data points, n = 2). D, A brief application of NMDA alone induced a transient but not sustained increase in mIPSC frequency (n = 5). E, Application of NMDA/glycine in a Ca²⁺-free ACSF did not induce a lasting change in mIPSC frequency (n = 8). F, Inclusion of 10 or 20 mm BAPTA in the pipette solution did not prevent NMDAR-induced increase in mIPSC frequency (n = 8). G, Percentage change in mean mIPSC frequency of individual cells (open triangles; BAPTA: 10 mm, open triangles, and 20 mm, filled triangles) and average data (filled circles; *p < 0.02). Error bars indicate SEM.