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. 2006 Sep 6;26(36):9304–9311. doi: 10.1523/JNEUROSCI.0519-06.2006

Figure 1.

Figure 1.

α-Synuclein overexpression increases cytosolic catechol concentrations in PC12 cells. A, Representative Western blots of α-synuclein (α-Syn), TH, AADC, and superoxide dismutase 1 (loading control) in PC12 cells extracts. B, E, F, Relative protein levels (fold increase over control) of α-synuclein (B), TH (E), and AADC (F) in PC12 cells stably overexpressing EGFP, WT α-synuclein, or mutated A30P or A53T α-synuclein (mean ± SEM; n = 4–10 gels). C, D, Cytosolic concentrations of all catechol metabolites (C) and catecholamines (D) measured by IPE in cells treated with 100 μm l-DOPA for 1 h (mean ± SEM; n = 20–54 cells in different groups). p < 0.05 versus *EGFP or versus **EGFP and WT groups by Kruskal–Wallis test.