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. 2006 Nov 1;26(44):11387–11396. doi: 10.1523/JNEUROSCI.3349-06.2006

Figure 6.

Figure 6.

Nuclear PAD4 and TNF-α in TGK21and TG6074 brains. A, Quantitation of TNF-α in whole-brain homogenates from TGK21 (+), TG6074 (+), and nontransgenic littermates (−) from 2-week-old TGK21 (preclinical), 4-week-old TGK21 (clinical), 4-week-old TG6074 (preclinical), and 6-week-old TG6074 (clinical) mice (p < 0.001). B, Relative PAD4 levels in TGK21 (+) and TG6074 (+) transgenic mouse brains compared with nontransgenic (−) littermates at 2, 4, and 6 weeks of age. C, Ratios of nuclear citrullinated proteins/H3 ± SD in brain nuclear protein extracts from individual TGK21 (+) and TG6074 (+) transgenic mice compared with nontransgenic littermates (−). The means of the H3cit/H3 ratios for the TGK21and TG6074 transgenic mouse groups compared with their nontransgenic littermates are represented by the horizontal lines (p < 0.001, nonparametric test).

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