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. 2006 Nov 1;26(44):11295–11303. doi: 10.1523/JNEUROSCI.1794-06.2006

Figure 4.

Figure 4.

NRG 1β-induced suppression of α7 currents was blocked by ErbB inhibitor PD 158780 (10 μm). A, Sample recordings of ACh-evoked fast currents before (a), 15 min after perfusion with PD 158780 (b), and 21 min after washout (c). B, Averaged fast current amplitudes (percentage of T = 0; mean ± SEM; n = 6 cells) plotted versus time (minutes) in controls, in the presence of PD 158780, and in the presence of PD 158780 plus NRG 1β (5 nm). Note that PD 158780 alone produced a small but consistent increase in the α7 currents. C, Sample recordings of ACh-evoked biphasic currents before (a), 18 min after perfusion with PD 158780 (b), and 21 min after washout (c). D, Averaged fast α7 component amplitudes (percentage of T = 0; mean ± SEM; n = 6 cells) plotted versus time (minutes) in controls, in the presence of PD 158780, and in the presence of PD 158780 plus NRG 1β (5 nm). PD 158780 also blocked the effects of NRG 1β. A small increase in ACh currents in the presence of PD 158780 is evident.