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Epo and EpoR expression and neurogenesis defects in null animals. a–f, In situ hybridization of transverse sections with EpoR (a, c, e) or Epo (b, d, f) antisense probes on E8.5, E9.5, and E10.5 embryos. Inset photomicrographs are higher-magnification images from the neuroepithelium (a, c) and neural crest (e). g–l, Epo- (k, l) and EpoR- (g–j) deficient embryos show underdeveloped choroids plexus (i–l) and forebrain (g, h) at E13.5. Con, Control; Mut, mutant.
