Table 3.
Percentage colocalization of BrdU-labeled cells with phenotypic markers
| Structure | Antigen | Group |
|||
|---|---|---|---|---|---|
| Control | Nondyskinetic | Dyskinetic 0 weeks | Dyskinetic 4 weeks | ||
| Striatum | NeuN | 1.00 ± 0.57 | 0 | 0 | 1.40 ± 0.69 |
| NG2 | 86.96 ± 1.69 | 77.12 ± 6.26 | 41.57 ± 13.42*,** | 39.65 ± 3.01*,** | |
| RECA-1 | 11.38 ± 0.58 | 18.20 ± 2.64 | 60.08 ± 3.90*,** | 62.11 ± 9.20*,** | |
| Globus pallidus | NeuN | 0 | 0 | 0 | 0.80 ± 0.49 |
| NG2 | 82.76 ± 1.73 | 73.13 ± 7.09 | 41.11 ± 12.18*,** | 33.11 ± 5.38*,** | |
| RECA-1 | 9.39 ± 0.66 | 21.82 ± 5.69 | 55.37 ± 5.04*,** | 61.60 ± 3.99*,** | |
| Entopenduncular nucleus | NeuN | 0 | 0 | 0 | 0.60 ± 0.60 |
| NG2 | 82.74 ± 3.99 | 67.12 ± 3.28 | 21.02 ± 4.17*,** | 21.39 ± 3.75*,** | |
| RECA-1 | 7.11 ± 0.56 | 20.87 ± 3.50* | 85.12 ± 5.55*,** | 80.01 ± 6.07*,** | |
| Substantia nigra pars reticulata | NeuN | 0.67 ± 0.67 | 0 | 0 | 2.80 ± 0.97 |
| NG2 | 78.84 ± 5.58 | 58.58 ± 2.29* | 15.35 ± 2.54*,** | 19.95 ± 2.43*,** | |
| RECA-1 | 5.81 ± 1.01 | 29.39 ± 9.98* | 86.10 ± 1.95*,** | 75.64 ± 1.13*,** | |
One hundred randomly selected BrdU-positive cells per structure per animal were examined for colocalization with phenotypic markers of neurons (NeuN), oligodendrocytic precursors (NG2), and endothelial cells (RECA-1). The analysis was performed on the side ipsilateral to the 6-OHDA lesion. n = 4 for all groups.
*p < 0.05 versus control;
**p < 0.05 versus nondyskinetic rats.