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. 2006 Oct 4;26(40):10270–10280. doi: 10.1523/JNEUROSCI.3091-06.2006

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Copyright © 2006 Society for Neuroscience 0270-6474/06/2610270-11$15.00/0

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Figure 1. — NMDA and the group I mGluR agonist DHPG both elicit LTD of synaptic transmission at Schaffer collateral–CA1 synapses. A, Time course of LTD induced by bath-applied NMDA (10 μm, 3 min; filled bar), plotting normalized Schaffer collateral-evoked EPSC peak amplitudes recorded with whole-cell patch clamp from CA1 pyramidal cells (n = 6). B, Time course of LTD induced by bath-applied (S)-DHPG (25 μm, 5 min; filled bar), plotting normalized Schaffer collateral-evoked EPSC peak amplitudes recorded with whole-cell patch clamp from CA1 pyramidal cells (n = 6). Each point is mean ± SEM. EPSC peak amplitude is from n cells. Insets, Sample averaged evoked EPSCs (n = x) recorded at the times indicated by bars 1 and 2.