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. 2006 Oct 4;26(40):10270–10280. doi: 10.1523/JNEUROSCI.3091-06.2006

Figure 2.

Figure 2.

NMDA-LTD is associated with a long-term increase in PPF, whereas mGluR-LTD is not. A, Average EPSCs (mean of 8–10 traces) in a single CA1 pyramidal neuron evoked by paired-pulse stimuli (30 ms interstimulus interval) before (solid trace) and 30 min after (dotted trace) induction of NMDA-LTD by bath application of 10 μm NMDA for 3 min. Calibration: 50 pA, 25 ms. B, Plot of PPF in each individual experiment (open circles) and mean ± SEM. PPF (filled circles) before versus 30 min after induction of NMDA-LTD (10 μm, 3 min). NMDA-LTD was associated with a significant increase in PPF (*p < 0.05, paired t test). C, Average EPSCs (mean of 8–10 traces) in a single CA1 pyramidal neuron evoked by paired-pulse stimuli (30 ms interstimulus interval) before (solid trace) and 30 min after (dotted trace) induction of mGluR-LTD by bath application of 25 μm (S)-DHPG for 5 min. Calibration: 100 pA, 25 ms. D, Plot of PPF in each individual experiment (open circles) and mean ± SEM. PPF (filled circles) before (Control) and 30 min after induction of mGluR-LTD [25 μm (S)-DHPG, 5 min]. mGLuR-LTD was not associated with any change in PPF (p > 0.20, paired t test).