Table 2.

Summary of multiple regression peaks testing the model of a nonlinear trajectory of fMRI activation across the continuum of impairment

Region	Peak			Z value
	x	y	z
Pos-TRC
LH, Hippocampus	−21	−30	−9	5.46
RH, Hippocampus	24	−6	−18	5.51
LH, Inferior frontal gyrus	−36	27	−6	5.60
RH, Inferior frontal gyrus	39	27	−6	4.31
LH, Cingulate gyrus	−6	15	42	4.92
RH, Dorsolateral prefrontal cortex	54	24	24	5.75
Neg-TRC
LH, Posterior cingulate	−3	−42	21	5.41
LH, Anterior cingulate	−3	54	3	6.34
RH, Precuneus	3	−60	54	6.72
LH, Lateral parietal cortex	−54	−45	33	6.48
RH, Lateral parietal cortex	51	−51	12	5.77
Sec-C (Positive activity)
LH, Inferior frontal gyrus	−39	21	9	5.41
LH, Posterior cingulate	−3	−24	33	4.95
LH, Dorsal anterior cingulate	−3	18	42	6.45

SPM model: (NC = 3 < low-SB MCI = 4 ≫ high-SB MCI = 2 > AD = 1). LH, Left hemisphere; RH, right hemisphere.