Figure 3.

Number of genes changed (upregulated or downregulated) at p < 0.01 of rats killed at three post-SE stages, D (1 d), W (1 week), and M (3–4 months post-SE), for the CA3 and EC region and the CB. The panels show the average signal expression for the total set of changed genes and accompanying Venn diagrams in which the numbers of downregulated (blue) and upregulated (red) genes exclusively in each area and simultaneously in two or three areas are indicated. For example, in b, 100 were upregulated only in CA3, and 419 only in EC; additionally, 356 were upregulated in both; thus, the fraction of genes that changed in both areas was 77% for CA3 (356 of 464), and for EC (356 of 786), the fraction was 45%. The FDR is indicated in blue (next to each circle).