Figure 8.

Expression of genes related to synaptic transmission and plasticity. Changes in gene expression in the three regions after SE related to synaptic transmission (a) and plasticity (b). Graphs show the signal intensity of six to eight genes in CA3, EC, and CB in the non-SE group (nS), the control group (C), 1 d after SE (D), 1 week after SE (W) and during the chronic phase (M). The statistics of the genes within the GO process are displayed in a color-coded map next to each graph. Notice that most but not all of the synaptic proteins are downregulated after SE and recover to a large extent during epileptogenesis. b, Plasticity-related genes such as the CaMKIIa are downregulated after SE and remain so during all three phases. Protein kinase C δ (Prkcd) and brain-derived neurotrophic factor (Bdnf) are still upregulated during the chronic epileptic phase in CA3 and EC. Gene abbreviations are presented in Table 4.