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. 2006 Oct 25;26(43):11162–11173. doi: 10.1523/JNEUROSCI.3260-06.2006

Figure 7.

Figure 7.

Increased sensitivity to kainate-induced seizures in R236H/+ mice. A, Seizure severity was scored at 5 min intervals in animals injected with 20 mg/kg kainic acid. R236H/+ animals showed a significant increase in the severity of seizures compared with wild-type mice over the 3 h postinjection period (p < 0.0001, two-way ANOVA; *p < 0.05, Bonferroni posttests; error bars indicate SEM). B, Maximal seizure scores during the observation period were recorded for R236H/+ mice and controls. A higher proportion of mutant mice achieve seizure scores of 5 or higher (*p = 0.0138, Fisher's exact test). C–H, Histochemical analysis of the hippocampus with standard H&E staining (C–E) or FluoroJade B staining (F–H) reveals cell death in CA1 and CA3 (CA1 shown) in animals with severe seizures scoring ≥5 (E, H) (R236H/+ shown), compared with animals with maximal seizure scores <5, which show no cell death regardless of genotype (C, F, wild-type; D, G, R236H/+). n = 20 for each genotype (10 males, 10 females, 3 months old).