Table 4.
Top 50 OPC-specific expressed genes
| Probe set ID | OPC level | Fold change | Gene name | Gene symbol |
|---|---|---|---|---|
| AF023087_s_at | 10,328 | −6.36 | Early growth response 1 | EGR1 |
| AF030089UTR#1_at | 8350 | −5.82 | Activity and neurotrans.-induced early gene 4 | ANIA4 |
| rc_AA955914_s_at | 7687 | −4.76 | Fibrillarin | FBL |
| rc_AI235043_f_at | 5200 | −5.58 | Ubiquitin carboxyl-terminal hydrolase L1 | UCHL1 |
| M74223_at | 5120 | −11.79 | VGF nerve growth factor inducible | VGF |
| rc_AA943363_at | 4284 | −6.92 | Adenylate cyclase activ. polypep. 1 rec. type I | ADCYAP1R1 |
| rc_AI639082_s_at | 4249 | −9.19 | Mini chromosome maintenance deficient 6 | MCM6 |
| rc_AA964562_at | 4034 | −4.66 | ESTs, no homologies found | |
| rc_AA899649_at | 3766 | −5.82 | Stathmin-like 3 | STMN3 |
| X62952_at | 3693 | −25.11 | Vimentin* | VIM |
| D14014_g_at | 3686 | −5.86 | Cyclin D1 | CCND1 |
| X07944exon#1–12_s_at | 3418 | −5.17 | Ornithine decarboxylase 1 | ODC1 |
| rc_AA851497_f_at | 3234 | −4.35 | Hemoglobin, α1 | HBA1 |
| L25387_g_at | 3120 | −5.70 | Phosphofructokinase, liver, B-type | PFKL |
| rc_AA893471_s_at | 3062 | −7.26 | Reelin | RELN |
| J03624_at | 2821 | −18.00 | Galanin | GALN |
| M81642_at | 2779 | −4.92 | Coagulation factor II (thrombin) receptor | F2R |
| rc_AA892791_at | 2776 | −4.86 | Excision repair cross-complementing 1 | ERCC1 |
| rc_AI179576_s_at | 2506 | −13.27 | Hemoglobin, β | HBB |
| rc_AA945604_at | 2501 | −4.14 | Dimethylarginine dimethylaminohydrolase 1 | DDAH1 |
| U64030_at | 2420 | −8.28 | Deoxyuridinetriphosphatase (dUTPase) | DUTP |
| rc_AI008396_at | 2374 | −5.74 | Uridine monophosphate synthetase | UMPS |
| rc_AA899106_at | 2333 | −9.85 | Cyclin D2 | CCND2 |
| rc_AI013911_at | 2307 | −6.63 | RNA binding motif (RNP1, RRM) protein 3 | RBM3 |
| rc_AI069958_at | 2297 | −5.21 | Zinc finger, CCHC domain containing 12 | ZCCHC12 |
| L21192_at | 2253 | −5.82 | Growth associated protein 43 | GAP43 |
| rc_AA945679_s_at | 2238 | −7.89 | ESTs, no homologies found | |
| rc_AI179610_at | 2215 | −4.50 | Heme oxygenase | HMOX1 |
| AF069782_at | 2205 | −5.78 | Nucleolar protein 5 | NOL5 |
| rc_AA899590_at | 2201 | −27.47 | ESTs, no homologies found | |
| rc_AA901183_at | 2195 | −4.06 | Rat 45S rDNA gene transcrip. initiation region | |
| rc_AA850706_at | 2045 | −8.11 | SPARC related modular calcium binding 1 | SMOC1 |
| J03627_at | 1855 | −37.01 | S100 calcium binding protein A10 | S100A10 |
| M93669_at | 1827 | −49.52 | Secretogranin II | SCG2 |
| rc_AI014091_at | 1812 | −17.88 | Cbp/p300-interacting transactivator | CITED2 |
| X70871_at | 1806 | −8.17 | Cyclin G1* | CCNG1 |
| rc_AI112758_at | 1768 | −4.50 | Kinesin family member 21B | KIF21B |
| rc_AA858636_at | 1736 | −4.92 | Mini chromosome maintenance deficient 7 | MCM7 |
| D38222_s_at | 1735 | −4.17 | Protein tyrosine phosphatase, receptor type, N | PTPRN |
| rc_AA924772_at | 1719 | −7.26 | Metallothionein 3 | MT3 |
| rc_AI008836_s_at | 1712 | −6.82 | High mobility group box 2 | HMGB2 |
| rc_AA945835_at | 1700 | −5.24 | Formin binding protein 1-like | FNBP1L |
| U33553_at | 1686 | −5.74 | Neuroglycan C | CSPG5 |
| rc_AA859088_at | 1624 | −25.81 | Synaptotagmin 4* | SYT4 |
| rc_AA899854_at | 1589 | −25.81 | Topoisomerase (DNA) 2α | TOP2A |
| X59864mRNA_g_at | 1582 | −13.83 | H19 fetal liver mRNA | H19 |
| rc_AI230284_at | 1566 | −4.11 | Tropomycin 4 | TPM4 |
| M91652compl_seq_g_at | 1534 | 7.16 | Glutamine synthetase* | GLUL |
| rc_AI101481_at | 1460 | −4.14 | CaM kinase IIβ | CAMK2B |
| rc_AA943506_at | 1451 | −4.38 | Sprouty-related, EVH1 domain containing 2 | SPRED2 |
The 50 unique genes most strongly expressed specifically in undifferentiated OPCs are listed. Genes listed in bold are present in both Tables 3 and 4. In cases in which more than one Affymetrix probe set (Probe set ID) corresponding to the same gene was highly expressed, only the most strongly expressed is listed. OPC level, Raw expression level at the OPC time point. Fold change, Highest expression level/lowest expression level in time course; negative numbers are downregulated relative to OPCs. Genes that show a 2A expression pattern are denoted by an asterisk (*). Note that M81225_at (FNTA, 2103 at OPC time point), rc_AI233362_at (LAMP1, 1911 at OPC), rc_AA848813_at (REEP5, 1851 at OPC), and rc_AI102031_at (BIN1, 1687 at OPC) were excluded because they are more highly expressed in mature OLs.