Table 5.
Regulated genes associated with MS-linked loci
| Probe set ID | Peak level | Fold change | r-UniGene | h-UniGene | h-Chromosome | Gene name | Gene symbol |
|---|---|---|---|---|---|---|---|
| rc_AA944463_at | 294 | −3.86 | Rn.7736 | Hs.471200 | 2q33.3; 206 Mb | Neuropilin 2 | NRP2 |
| rc_AI230247_s_at | 606 | 22.32 | Rn.1451 | Hs.275775 | 5p12; 43 Mb | Selenoprotein P, plasma, 1 | SEPP1 |
| rc_AA893970_at | 1425 | 4.26 | Rn.12956 | Hs.407926 | 5p13.1; 39 Mb | TORC2-specific protein AVO3 | RICTOR |
| X62875mRNA_g_at | 731 | −4.47 | Rn.83614 | Hs.518805 | 6p21.31; 34 Mb | High mobility group AT-hook 1 | HMGa1 |
| rc_AI229707_s_at | 727 | −6.11 | Rn.2458 | Hs.533059 | 6p21.33; 31 Mb | Tubulinβ5 chain | TUBB |
| rc_AI012221_at | 1413 | −11.16 | Rn.101003 | Hs.414565 | 6p21.33; 32 Mb | Chloride intracellular channel 1 | CLIC1 |
| M99485_at | 3636 | 97.68 | Rn.9687 | Hs.141308 | 6p22.1; 30 Mb | Myelin oligodendrocyte glycoprotein | MOG |
| rc_AA925012_at | 1711 | −10.48 | Rn.15438 | Hs.234896 | 6p22.2; 25 Mb | Geminin | GMNN |
| rc_AI169703_at | 581 | −3.78 | Rn.137382 | Hs.484813 | 6p22.3; 18 Mb | DEK oncogene (DNA binding) | DEK |
| rc_AA891734_at | 2285 | 7.46 | Rn.54151 | Hs.520814 | 7p12.3; 47 Mb | Tensin-like SH2 domain containing 1 | TENS1 |
| rc_AA998383_at | 424 | −6.28 | Rn.98822 | Hs.119882 | 7q21.2; 92 Mb | Cyclin-dependent kinase 6 | CDK6 |
| rc_AI233394_at | 119 | 7.62 | Rn.8331 | Hs.116796 | 11q23.1; 111 Mb | DIX domain containing 1 | DIXDC1 |
| M55534mRNA_s_at | 638 | 5.13 | Rn.98208 | Hs.408767 | 11q23.1; 111 Mb | Crystallin,αB | CRYAB |
| rc_AI232128_at | 901 | 5.46 | Rn.19811 | Hs.47115 | 16q22.2; 70 Mb | Hydrocephalus inducing | HYDIN |
| rc_AI073086_at | 1031 | 3.68 | Rn.17753 | Hs.531704 | 17q24.2; 62 Mb | Protein kinase C,α | PRKCA |
| rc_AI231497_at | 1171 | −11.31 | Rn.2949 | Hs.159557 | 17q24.2; 63 Mb | Karyopherinα2 | KPNA2 |
| rc_AI045866_at | 349 | −3.76 | Rn.16334 | Hs.549130 | 17q24.2; 63 Mb | PI transfer protein, cytoplasmic 1 | PITPNC1 |
| rc_AI233288_at | 493 | 7.46 | Rn.19813 | Hs.463964 | 17q24.2; 64 Mb | WD40 repeat protein Interact with PI | WIPI49 |
| rc_AI009456_at | 1539 | 13.74 | Rn.22789 | Hs.58351 | 17q24.2; 64 Mb | ATP-binding cassette transporter 8a | ABCA8 |
| rc_AA818774_at | 1368 | 12.13 | Rn.16666 | Hs.27935 | 17q25.1; 70 Mb | Tweety homolog 2 | TTYH2 |
| rc_AI230702_at | 910 | −5.13 | Rn.104570 | Hs.532803 | 17q25.1; 71 Mb | Hematological and neurological EST 1 | HN1 |
| rc_AI012571_at | 535 | −4.99 | Rn.12319 | Hs.501423 | 19p13.3; 3 Mb | Bruno-like 5, RNA binding protein | BRUNOL5 |
Genes regulated during OL differentiation tightly linked to multiple sclerosis susceptibility loci. Genes highly regulated during OL differentiation that lay within 2 Mb of human genomic loci linked to cases of multiple sclerosis in three or more independent clinical studies (Fernald et al., 2005). Peak level, Highest raw expression level reached in the time course. Fold change, Highest expression level/lowest expression level in time course; if highest expression level precedes lowest expression level, expressed as negative fold change. r- and h-UniGene, respectively, The rat and closest human homolog UniGene clusters associated with the indicated probe set. h-Chromosome, The cytoband and location in megabases from the end of the p-arm for each listed human UniGene cluster.