Figure 8.

Inhibitors of PKC blocked the increase in glutamate uptake during E-LTP. A, Two different inhibitors of PKC, Chelerythrine (10 μm) and GF 109203X (0.5 μm), had inhibitory effects on the induction of E-LTP (n = 5). Chelerythrine and GF 109203X were applied from 15 min before HFS to 15 min after HFS. B, The two different PKC inhibitors applied during HFS blocked the increase in glutamate uptake observed 30 min after HFS (n = 5 for each inhibitor). Chelerythrine or GF 109203X treatments by themselves for 30 min had no effect on glutamate uptake measured 30 min later (data not shown). Data were analyzed using a one-way ANOVA (F_(2,12) = 8.8; p < 0.01), and post hoc analysis was done by Tukey–Kramer's test. *Statistically different, p < 0.05. Error bars indicate SEM. Chel, Chelerythrine.