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. 2006 Oct 11;26(41):10452–10460. doi: 10.1523/JNEUROSCI.2850-06.2006

Figure 4.

Figure 4.

Forebrain stem cells from symptomatic R6/2 mice display enhanced self-renewal induced cell non-autonomously in the R6/2 brain, but, once induced, this enhanced self-renewal is maintained in vitro. A, Serial bulk passaging of neurosphere colonies from symptomatic, 12-week-old R6/2 and WT mice forebrains. Bulk passages were performed every 7 d. B, Bulk passages of neurosphere colonies from presymptomatic R6/2 and WT mice (at 4.5 weeks of age) over 6 weeks yields equivalent numbers of neural stem cells. All data are expressed as mean ± SEM. *p < 0.05.