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. 2006 Oct 11;26(41):10407–10419. doi: 10.1523/JNEUROSCI.3257-06.2006

Figure 12.

Figure 12.

Model of KCC2 activation in the LSO. In immature LSO neurons, monomeric KCC2 is present in the plasma membrane. Because the monomeric KCC2 is transport inactive, LSO neurons exhibit a relative high [Cl−]i. Development-dependent oligomerization activates KCC2, thereby lowering [Cl−]i. This change in [Cl−]i results in a developmental shift from depolarization to hyperpolarization (D/H-shift). Hatched ovals represent glycine receptors (GlyR), and filled ovals represent individual KCC2 polypeptides.