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. 2006 Oct 11;26(41):10536–10541. doi: 10.1523/JNEUROSCI.3133-06.2006

Figure 1.

Figure 1.

Increased Aβ levels in p25 Tg mice. a, Aβx-42 and Aβx-40 levels were determined by ELISA using capture antibodies 21F12 and 2G3 that specifically recognize mouse Aβx-42 and Aβx-40, respectively. Data are mean ± SEM values for WT (n = 5) and CK–p25 Tg (n = 5) mice. APP−/− indicates APP knock-out brain lysate used as negative control. b, Aβ levels are not increased in uninduced p25 Tg mice. Data are mean ± SEM values for WT (n = 3) and CK–p25 Tg (n = 3) mice. Aβx-42 levels were unchanged, whereas there was a small but significant decrease in Aβx-40 levels in uninduced p25 Tg mice compared with WT. c, Human Aβ levels in PD-APP/CK–p25 mice were determined by ELISA. Data are mean ± SEM values for PD-APP (n = 3) and CK–p25/PD-APP (n = 3) mice. d, Insoluble human Aβ levels were determined by ELISA from RIPA-insoluble pellet fraction from forebrain lysates of PD-APP and CK–p25/PD-APP mice induced for 8 weeks. Data are mean ± SEM values for PD-APP (n = 3) and CK–p25/PD-APP (n = 3) mice. **p < 0.005, by two-tailed, unpaired Student's t test.