Table 7.
A summary of some of the major features examined in the neuromuscular system of Bax KO and MyoGDNF mice
| Bax KO | MyoGDNF | |
|---|---|---|
| MN number | ↑ complete rescue | ↑ partial rescue |
| Axon number | ||
| VR myl | ↑ | ↑ |
| VR unmyl | ↑ | = WT |
| MG | ↑ | ↑ |
| Facial | ↑ | = WT |
| MN soma size | ↓ | ↓ |
| MN axon size | ↓ | ↓ |
| Retrograde labeling | ↑ facial | n.d. |
| NMJs | = WT | = WT |
| Dendrites | ||
| Primary | = WT | = WT |
| Density | = WT | ↑ |
| MN synapses | = WT | n.d. |
| MN ultrastructure | = WT | n.d. |
| Muscle | ||
| Extrafusal | = WT | Altered (see text; Fig. 5) |
| Intrafusal (number of spindles) | ↑ | = WT |
| MN phenotype | ||
| ChAT | = WT | = WT |
| AChE | = WT | = WT |
| VAchT | = WT | = WT |
| HB9 | = WT | = WT |
| Islet-1 | = WT | = WT |
| c-Ret | = WT | = WT |
| GFRα1 | = WT | = WT |
| α3NKA | ↑ | ↑ |
| MN physiology | = WT | Altered (see text; Table 3) |
| Behavior | Altered (see text; Fig. 6) | Altered (see text; Fig. 6) |
↑Increased relative to WT; ↓decreased relative to WT; unmyl, unmyelinated; myl, myelinated; MG, medial gastrocnemius; VAchT, vesicular acetylcholine transporter; n.d., not determined; = WT, similar to WT.