Table 1.
ERG a-wave and b-wave data from CNTF- and PBS-treated rats
| Treatment | a-wave amplitudea (μV) | b-wave Vmaxb (μV) | b-wave kb (log cd · s/m2) | a-wave CNTF/PBS ratio | b-wave CNTF/PBS ratio | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| 6 d | ||||||||||
| PBS (n = 8) | 584 ± 81 | p < 0.01 | 1543 ± 224 | p < 0.05 | −3.50 ± 0.10 | p < 0.05 | 0.38 ± 0.09 | p < 0.01 | 0.59 ± 0.12 | p < 0.05 |
| CNTF (n = 8) | 194 ± 44 | 774 ± 165 | −3.08 ± 0.09 | |||||||
| 21 d | ||||||||||
| PBS (n = 8) | 466 ± 77 | NS | 1116 ± 134 | NS | −3.42 ± 0.06 | NS | 1.08 ± 0.16 | NS | 1.03 ± 0.16 | NS |
| CNTF (n = 8) | 438 ± 54 | 1063 ± 132 | −3.36 ± 0.05 |
aAmplitude at the maximum intensity (0.6 log cd · s/m2).
bNaka–Rushton function fit to scotopic b-wave data.
Values are mean ± SEM. p values were calculated using the repeated-measures two-way ANOVA (matching across time), followed by the Bonferroni's post hoc test for specific comparisons. For a-wave amplitude and b-wave Vmax, raw amplitudes were used. For ratios, values were first converted to logarithms to convert the differences to ratios. The log intensity values were used to calculate the p values for k. All measurements showed a significant effect of treatment (p < 0.01, a-wave; p < 0.05, b-wave and k) overall and interaction of time and treatment (p < 0.05) but no significant effect of time.