Table 2.

Neurochemical measure of nigrostriatal innervation in C57BL/6 mice chronically treated with vehicle, SCH58261, or KW-6002 after a unilateral 6-OHDA lesion

Treatment	DA (pmol/mg tissue)	DOPAC (pmol/mg tissue)
KW-6002
Vehicle treated (n = 7)
Ipsilateral	4 ± 1*	0.4 ± 0.3*
Contralateral	108 ± 7	5.7 ± 0.3
KW-6002, 0.03 mg/kg (n = 9)
Ipsilateral	2 ± 1*	0.4 ± 0.2*
Contralateral	95 ± 5	5.3 ± 0.8
KW-6002, 0.3 mg/kg (n = 9)
Ipsilateral	4 ± 2*	0.7 ± 0.3*
Contralateral	96 ± 8	4.6 ± 0.5
SCH58261
Vehicle treated (n = 17)
Ipsilateral	3 ± 1*	0.3 ± 0.1*
Contralateral	96 ± 4	4.3 ± 0.2
SCH58261, 0.03 mg/kg (n = 16)
Ipsilateral	3 ± 1*	0.3 ± 0.1*
Contralateral	98 ± 5	4.5 ± 0.3

DA and DOPAC were determined in striatal homogenates obtained from animals that received the above treatment for 21 d. Mice were killed 1 month after the injection of 6-OHDA.

*p < 0.05 versus respective contralateral side.