Table 3.
Neurochemical measure of nigrostriatal innervation in wild-type and conditional A2A KO (cKO) mice chronically treated with l-DOPA after a unilateral 6-OHDA lesion
| Genotype | DA (pmol/mg tissue) | DOPAC (pmol/mg tissue) |
|---|---|---|
| Control | ||
| Ipsilateral | 1 ± 1* | 0.5 ± 0.2* |
| Contralateral | 54 ± 7 | 4.0 ± 0.6 |
| A2A cKO | ||
| Ipsilateral | 2 ± 1* | 0.4 ± 0.2* |
| Contralateral | 58 ± 6 | 4.3 ± 0.8 |
DA and DOPAC were determined in striatal homogenates obtained from animals that received the above treatment for 21 d. Mice were killed 24 h after the last l-DOPA dose and 1 month after the injection of 6-OHDA.
*p < 0.05 versus respective contralateral side.