Table 1.
Values of the model parameters that were adjusted to fit the experimental data
| Cell group | Stimulation object | Initial release probability per vesicle α1 | Initial readily releasable pool size n1 | Initial release probability P1 | Increment in CaXKAR after a stimulus, ΔKAR (normalized) | Decay constant of CaXKAR, τKAR (ms) |
|---|---|---|---|---|---|---|
| Pyramidal cells | Paired-pulse ratio versus interval | 0.037 | 5.0 | 0.17 | 0 | NA |
| Five-pulse ratio versus frequency | 0.037 | 5.0 | 0.17 | 0 | NA | |
| Non-EGFP interneurons | Paired-pulse ratio versus interval | 0.090 | 8.0 | 0.52 | 0 | NA |
| Five-pulse ratio versus frequency | 0.090 | 8.0 | 0.52 | 0 | NA | |
| EGFP-expressing SOM interneurons control | Paired-pulse ratio versus interval | 0.025 | 5.0 | 0.12 | 5 | 25 |
| Five-pulse ratio versus frequency | 0.025 | 5.0 | 0.12 | 5 | 25 | |
| EGFP-expressing SOM interneurons in NS-102 | Paired-pulse ratio versus interval | 0.025 | 5.0 | 0.12 | 0 | NA |
| Five-pulse ratio versus frequency | 0.025 | 5.0 | 0.12 | 0 | NA |
All parameters are independent variables except P1, which was calculated from the values of α1 and nT (for model description, see Appendix).