Figure 4.

Effects of post-training injections of compounds during late consolidation phase of fear conditioning. A, Scheme showing manipulations performed in this series of experiments. A 100 s trial (B) was used to evaluate the baseline response to the conditioned context (CC+) before training. Compounds were injected 6 h after initiation of training. B, Among injected compounds, only PSA-NCAM-Fc impaired contextual memory tested in CC+ on the first and third days after training (trials 1 and 3, respectively). Mice injected with the Fc-fragment (Fc) and chondroitin sulfate (CHS) served as controls. There was no difference between injected groups during trial B. C, Post-training injection of compounds did not affect cued memory and discrimination between paired (CS+) versus unpaired (CS−) tones. ^##p ≤ 0.01 (ANOVA); **p ≤ 0.01 (post hoc FLSD test as compared with Fc for day 1); ⁺p < 0.05 (Wilcoxon test).