Figure 5.

Fear conditioning of PST-deficient mice (PST−/−) and corresponding wild-type controls (PST+/+). A, PST−/− mice showed significantly less freezing in the conditioned context (CC+) compared with PST+/+ mice. A 100 s trial (B) was used to evaluate the baseline response to the conditioned context (CC+) before training. There was no difference between groups during trial B. B, Cued memory was normal on the second and third days after fear conditioning (trials 2 and 3) in PST−/− mice. Discrimination of paired (CS+) versus unpaired (CS−) tones also did not differ between genotypes. ^###p ≤ 0.005 (ANOVA); *p ≤ 0.05, ***p ≤ 0.005 (post hoc FLSD test; as compared with PST+/+ for corresponding days); ⁺p < 0.05 (Wilcoxon test).