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. 2006 Oct 18;26(42):10847–10855. doi: 10.1523/JNEUROSCI.3023-06.2006

Figure 8.

Figure 8.

Steady-state activation and inactivation characteristics of TTX-resistant Na+ currents in bladder afferent neurons with TTX-resistant spikes from vehicle-treated and NGF-treated rats (2 weeks). A, Inactivation characteristics of TTX-resistant Na+ currents in vehicle-treated animals (n = 15) (▴) and NGF-treated animals (n = 20) (▵). Peak amplitude of TTX-resistant Na+ currents normalized to the maximal amplitude of TTX-resistant Na+ currents (I/Imax) were plotted against membrane potentials. Vh and k obtained by fitting curves using the modified Boltzmann equation were −33.3 mV and −6.0 for vehicle-treated rats and −34.1 mV and −6.2 for NGF-treated rats. B, Activation characteristics of TTX-resistant Na+ currents obtained in the neurons from vehicle-treated animals (n = 15) (■) and NGF-treated animals (n = 20) (□). Na+ conductances normalized to the maximal Na+ conductance (G/Gmax) were plotted against membrane potentials. Vh and k obtained by fitting curves using the modified Boltzmann equation were −11.9 mV and 8.2 for vehicle-treated rats and −10.1 mV and 8.7 for NGF-treated rats. Error bars indicate SE.