Figure 3.
Expression of SLRs requires AIN activity mediated by glutamatergic synaptic transmission through mossy fiber synapses. Top, Sample traces from an individual subject during two test sessions in which presession infusions of the GABAA antagonist gabazine unmasked SLRs from the start of testing (red traces). Infusing the ionotropic glutamate receptor antagonists d-(−)-APV and CNQX into the AIN after trial 21 suppressed SLRs (left), whereas infusing ACSF did not (right). Bottom, Summary data of percentage SLRs as a function of 21-trial blocks during the two test sessions (glutamate antagonist session, red to blue; ACSF session, all red).