Figure 6.

Val-BDNF- and Met-BDNF-containing vesicles have similar transport dynamics. A, All vesicles in each cell were selected and tracked during 60 s. B, The mean velocity of all tracked vesicles showed no differences between Val-BDNF and Met-BDNF vesicles. C, Val-BDNF- and Met-BDNF-containing vesicles showed the same pattern of diffusion in wt cells, which was similarly reduced in mhtt cells. Val-BDNF in wt cells, 4795 measures; Met-BDNF in wt cells, 3627 measures; Val-BDNF in mhtt cells, 3761 measures; Met-BDNF in mhtt cells, 5177 measures. Results are represented as a mean ± SEM determined from analysis of three independent experiments (*p < 0.05; **p < 0.01; ***p < 0.001).