Figure 4.

Electron microscopy of cross sections of corpus callosum in wild-type and eNOS^−/− mice. A large number of axons are demyelinated in both wild-type and eNOS^−/− mice after 4 weeks of cuprizone exposure. Myelinated and unmyelinated axons in the corpus callosum were counted from three different electron micrograph images of each mouse at different time points of cuprizone feeding. Scale bar, 1 μm. *p < 0.05; **p < 0.01. n = 6–7 mice for each time point derived from two different experiments.