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The effect of proglumide on basal pain increase (A), basal ACTH increase (B), and basal cortisol increase (C) in test 1 (black symbols) is compared with proglumide in the nocebo condition of test 2 (white symbols). Note that, whereas proglumide suppressed nocebo hyperalgesia, it was ineffective in suppressing the nocebo increase of ACTH and cortisol plasma concentrations. **p < 0.01; ***p < 0.001.
