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The structural formula of the anxiolytic drug diazepam, one of the most used benzodiazepines, is similar to L-365,260, a benzodiazepine-based CCK antagonist, thus suggesting similar mechanisms of action of benzodiazepines and CCK antagonists. Note the higher binding affinity of L-365,260 for CCK-B receptors compared with CCK-A receptors, expressed as the concentration required to inhibit by 50% the specific binding of 125I-Bolton-Hunter CCK-8 (IC50).
