Table 3.

Parameters for simulation of removal of inactivation by trypsin

Condition	ko(s−1)	kc(s−1)	Po	ki (s−1)	kr(s−1)	Pi	kt* (s−1)	τd (s)	n
0 Ca2+, 0 mV	50	5000	0.01	12.5	1	0.93		28.0	3.95
10 Ca2+, −80 mV	50	950	0.05	12.5	50	0.2		25.3	4.00
10 Ca2+, 0 mV	2000	500	0.8	12.5	5	0.71		63.2	2.84
10 Ca2+, +60 mV	9800	200	0.98	12.5	0.2	0.98		1422.6	1.16
10 Ca2+, 0 mV	2000	500	0.8	12.5	1	0.93		225.8	1.64
10 Ca2+, 0 mV	2000	500	0.8	12.5	0.2	0.98		1140.5	1.19
10 Ca2+, 0 mV	2000	500	0.8	12.5	0.02	0.998		11443	1.05
Inactivated ID can be cleaved
0 Ca2+, 0 mV	50	5000	0.01	12.5	1	0.93	0.004	27.8	3.94
10 Ca2+, −80 mV	50	950	0.05	12.5	50	0.2	0.004	25.7	4.00
10 Ca2+, 0 mV	2000	500	0.8	12.5	5	0.71	0.004	54.6	3.07
10 Ca2+, +60 mV	9800	200	0.98	12.5	0.2	0.98	0.004	174.6	1.83
10 Ca2+, 0 mV	2000	500	0.8	12.5	1	0.93	0.004	108.3	2.24
10 Ca2+, 0 mV	2000	500	0.8	12.5	0.2	0.98	0.004	169.6	1.85
10 Ca2+, 0 mV	2000	500	0.8	12.5	0.2	0.98	0.002	305.0	1.52
10 Ca2+, 0 mV	2000	500	0.8	12.5	0.2	0.98	0.0004	714.4	1.3
10 Ca2+, 0 mV	2000	500	0.8	12.5	0.02	0.998	0.004	198.4	1.74
10 Ca2+, 0 mV	2000	500	0.8	12.5	0.02	0.998	0.002	407.44	1.43
10 Ca2+, 0 mV	2000	500	0.8	12.5	0.02	0.998	0.0004	1720.3	1.18

Parameters for different simulations are given in columns 2–8, whereas values obtained from fitting Equation 1 to the simulated time course are given in columns 9–10. Bold conditions in column 1 correspond to simulations displayed on Figure 6.