Table 3.
Condition | ko(s−1) | kc(s−1) | Po | ki (s−1) | kr(s−1) | Pi | kt* (s−1) | τd (s) | n |
---|---|---|---|---|---|---|---|---|---|
0 Ca2+, 0 mV | 50 | 5000 | 0.01 | 12.5 | 1 | 0.93 | 28.0 | 3.95 | |
10 Ca2+, −80 mV | 50 | 950 | 0.05 | 12.5 | 50 | 0.2 | 25.3 | 4.00 | |
10 Ca2+, 0 mV | 2000 | 500 | 0.8 | 12.5 | 5 | 0.71 | 63.2 | 2.84 | |
10 Ca2+, +60 mV | 9800 | 200 | 0.98 | 12.5 | 0.2 | 0.98 | 1422.6 | 1.16 | |
10 Ca2+, 0 mV | 2000 | 500 | 0.8 | 12.5 | 1 | 0.93 | 225.8 | 1.64 | |
10 Ca2+, 0 mV | 2000 | 500 | 0.8 | 12.5 | 0.2 | 0.98 | 1140.5 | 1.19 | |
10 Ca2+, 0 mV | 2000 | 500 | 0.8 | 12.5 | 0.02 | 0.998 | 11443 | 1.05 | |
Inactivated ID can be cleaved | |||||||||
0 Ca2+, 0 mV | 50 | 5000 | 0.01 | 12.5 | 1 | 0.93 | 0.004 | 27.8 | 3.94 |
10 Ca2+, −80 mV | 50 | 950 | 0.05 | 12.5 | 50 | 0.2 | 0.004 | 25.7 | 4.00 |
10 Ca2+, 0 mV | 2000 | 500 | 0.8 | 12.5 | 5 | 0.71 | 0.004 | 54.6 | 3.07 |
10 Ca2+, +60 mV | 9800 | 200 | 0.98 | 12.5 | 0.2 | 0.98 | 0.004 | 174.6 | 1.83 |
10 Ca2+, 0 mV | 2000 | 500 | 0.8 | 12.5 | 1 | 0.93 | 0.004 | 108.3 | 2.24 |
10 Ca2+, 0 mV | 2000 | 500 | 0.8 | 12.5 | 0.2 | 0.98 | 0.004 | 169.6 | 1.85 |
10 Ca2+, 0 mV | 2000 | 500 | 0.8 | 12.5 | 0.2 | 0.98 | 0.002 | 305.0 | 1.52 |
10 Ca2+, 0 mV | 2000 | 500 | 0.8 | 12.5 | 0.2 | 0.98 | 0.0004 | 714.4 | 1.3 |
10 Ca2+, 0 mV | 2000 | 500 | 0.8 | 12.5 | 0.02 | 0.998 | 0.004 | 198.4 | 1.74 |
10 Ca2+, 0 mV | 2000 | 500 | 0.8 | 12.5 | 0.02 | 0.998 | 0.002 | 407.44 | 1.43 |
10 Ca2+, 0 mV | 2000 | 500 | 0.8 | 12.5 | 0.02 | 0.998 | 0.0004 | 1720.3 | 1.18 |
Parameters for different simulations are given in columns 2–8, whereas values obtained from fitting Equation 1 to the simulated time course are given in columns 9–10. Bold conditions in column 1 correspond to simulations displayed on Figure 6.