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. 2006 Nov 15;26(46):11974–11986. doi: 10.1523/JNEUROSCI.3188-06.2006

Figure 5.

Figure 5.

L5 SNL enhances NGF/TrkA signaling in the undamaged L4 DRG neurons. A, Immunohistochemistry showing the phosphorylation of TrkA in the spared L4 DRG at day 7 after L5 SNL. B, Protein expression of p-TrkA in the L4 DRG at day 7 after surgery, as detected by Western blotting. C, Immunohistochemistry showing the phosphorylation of Trk in the spared L4 DRG at day 7 after L5 SNL. D, Immunohistochemical colocalization of green reaction product for p-Trk and red product for TrkA in the L4 DRG at day 7 after surgery. The open arrows indicate double-labeled neurons. E, Double staining for p-Trk and p75NTR revealed heavy colocalization in the L4 DRG at day 7 after surgery. F, Double labeling by a combined method of ISHH and immunohistochemistry for TrkB or TrkC mRNA and p-Trk-IR in the L4 DRG. The arrows indicate single-labeled neurons for p-Trk protein, whereas the arrowheads indicate single-labeled neurons for TrkB or TrkC mRNA. Data represent mean ± SD; n = 4 per group. *p < 0.05 compared with the naive control. Scale bars, 50 μm.