Figure 6.
An inward current underlies the sADP. A, Square pulses (left) or simulated action potentials (middle) were used as voltage commands to elicit the current underlying the sADP. Right shows comparison of simulated action potential (black) versus actual action potential (gray). B, Inward current (IADP) is elicited by voltage commands shown in A. B, C, Increasing the number of simulated spikes increases the current. D, Top, Voltage protocol to estimate input resistance before, during, and after induced IADP. Bottom, Corresponding current trace. E, Overlap of current trace from before and during IADP showing increased steady-state conductance during IADP. F, Changes in Isteady-state in all cells tested illustrating the increase in current and return to precommand levels. *p < 0.001.