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. 2006 Feb 15;26(7):1913–1922. doi: 10.1523/JNEUROSCI.3571-05.2006

Figure 1.

Figure 1.

OPC dispersal is reduced in the netrin-1 mutant spinal cord. A, B, Expression of PDGFαR in the E13.5 spinal cord. PDGFαR+ cells are widely dispersed in the ventral spinal cord (A). In contrast, cells are less widely dispersed in the mutant spinal cord (B), and there is a reduction in cell number. Note that ventral commissures are thinner in mutant spinal cords because of the commissural axon guidance defect in netrin-1 mutants (B, arrowhead). C, D, Localization of Olig2+ cells in the E13.5 spinal cord. Olig2+ cells are widely dispersed in the wild-type spinal cord (C) but more restricted to the ventral ventricular zone in mutant spinal cord (D). G–I, Distribution of PLP-EGFP+ cells in the netrin-1 background. At E16, PLP-EGFP+ OPCs are dispersed throughout the ventral and dorsal lumbar spinal cords in wild-type (E) and heterozygote (F). In netrin-1 mutants, however, OPCs accumulate at the ventral ventricular zone (G), and there is a reduction in cell number. Scale bars: A–D, 100 μm; E–G, 250 μm.