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. 2006 Feb 15;26(7):2010–2021. doi: 10.1523/JNEUROSCI.2599-05.2006

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Copyright © 2006 Society for Neuroscience 0270-6474/06/262010-12$15.00/0

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Figure 5. — 5-HT enhanced the A-current in VSI. A, Bath-applied 5-HT (10 μm) caused a 12% increase in the amplitude of A-current evoked by a depolarizing step to −20 mV from a holding potential of −90 mV. Inset, Averaged A-current waveforms obtained in control saline (1), in 5-HT (2), and after washout of 5-HT (3). B, Conductance–voltage relationships for A-current in VSI recorded in control saline (filled circles) and in 10 μm 5-HT (open circles). 5-HT caused an increase in A-current conductance at all voltages within the activation range. Inset, A-current responses evoked by voltage steps from −90 to −40, −30, and −20 mV. Calibration: A, B, insets, 5 nA; 200 ms. C, 4-AP blocked the 5-HT-induced enhancement of the outward current conductance. The peak amplitudes of the outward conductance were measured in the presence or absence of 10 μm 5-HT and 2 mm 4-AP. Asterisk indicates significant difference from control (p < 0.001). See Results for details.