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. 2006 Feb 15;26(7):1971–1978. doi: 10.1523/JNEUROSCI.2173-05.2006

Figure 6.

Figure 6.

HPA axis regulation after stress. a, Analysis of CORT secretion after restraint stress (n = 4–5) revealed that FBGRKO mice secrete significantly more (*) CORT after 5 and 15 min of restraint stress. Plasma CORT was also significantly higher in FBGRKO mice 60 min after the termination of restraint stress (p = 0.04), and a trend toward increased CORT secretion was found after 90 min in FBGRKO mice (†p = 0.06). b, FBGRKO mice secrete significantly more ACTH after 5 min of restraint stress compared with controls. c, FBGRKO mice secrete significantly more CORT 5, 15, and 30 min (p = 0.05) but not 60 or 90 min after mild stress. Two hours after stress, FBGRKO mice again showed increased plasma CORT compared with controls (p = 0.05). d, FBGRKO mice secrete significantly more ACTH 5 min after mild stress. e, No differences were found between genotypes in the release of CORT after ACTH stimulation. NS, Normal saline. f, Analysis of activity in the forced swim test (n = 4–6) revealed that, after restraint stress, both genotypes show increased activity, but FBGRKO mice maintain decreased activity relative to controls (p = 0.03).