Figure 3.

Post-stroke neurogenesis derives from a GFAP-expressing progenitor in the SVZ. a, b, DCX⁺ cells (red) colocalize entirely with GFP (green) expression in peri-infarct cortex of GFAP reporter mice producing large regions of overlap (yellow). A subpopulation of GFP⁺/DCX-negative cells is presumed to be astrocytes. The region within the box in a is enlarged in b. Scale bars, 25 μm. c, DCX⁺ cells (red) do not colocalize with β-galactosidase expression (green) in peri-infarct cortex of VE–cadherin reporter mice. Scale bar, 25 μm. d, DCX⁺ cells (red) are located in close physical proximity to β-galactosidase⁺ endothelial cells (green). Scale bar, 25 μm.