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. 2006 Dec 20;26(51):13384–13389. doi: 10.1523/JNEUROSCI.2514-06.2006

Figure 3.

Figure 3.

Accumulation of APP CTF does not change with age. A, B, Shown are representative photomicrographs of CTF immunoreactivity in subiculum in wild-type male (A) and 3xTg-AD (B) mice at age 7 months. C, Representative photomicrograph of Aβ immunoreactivity in subiculum in 7 month 3xTg-AD mouse. Scale bar, 25 μm. E–G Also shown are representative photomicrographs of CTF immunoreactivity in subiculum of sham GDX 3xTg-AD mice at ages 3 (E), 7 (F), and 13 (G) months. Scale bar, 50 μm. D, H, Aβ immunoreactivity in subiculum (solid bars) and hippocampus CA1 (open bars) was quantified by load values (means ± SEM) in sham GDX 3xTg-AD mice ages 3, 7, and 13 months (D) and 3xTg-AD mice age 7 months (H) in the sham GDX (Sham), GDX, and GDX plus DHT conditions.