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. 2006 Dec 20;26(51):13384–13389. doi: 10.1523/JNEUROSCI.2514-06.2006

Figure 4.

Figure 4.

Advancing age and androgen depletion increase behavioral deficits in 3xTg-AD mice. Shown is SAB, expressed as a percentage of alternation ± SEM, in wild-type (WT; open bars) and 3xTg-AD (solid bars) mice. A, SAB decreased with increasing age in sham GDX (Sham) 3xTg-AD mice. *p < 0.05 versus 7 month WT Sham group; # p < 0.05 versus 7 month Sham 3xTg-AD group. B, SAB was decreased by androgen depletion, an effect prevented by DHT treatment. *p < 0.05 versus 7 month sham group; # p < 0.05 versus 7 month GDX group.