Table 2. Prevalence of F3 and F4 fibrosis by different FIB-4 criteria.

		Overall Cohort		NAFLD/NASH ICD-9/10 Cohort
		N = 20,204,004		N = 208,749
	FIB-4 Categories	Prevalence (%)	95% CI	Prevalence (%)	95% CI
Criteria 1	F3/F4 > 2.67	3.12%	3.11–3.13%	6.90%	6.79–7.01%
Criteria 2	F4 > 4.12	0.71%	0.71–0.71%	2.52%	2.45–2.59%
	2.67 < F3 < = 4.12	2.41%	2.40–2.42%	4.38%	4.29–4.47%
Criteria 3	F4 > 3.5	1.21%	1.20–1.21%	3.67%	3.59–3.75%
	2.67 < F3 < = 3.5	1.91%	1.91–1.92%	3.23%	3.16–3.31%
Criteria 4	F4 > 3.5	1.21%	1.20–1.21%	3.67%	3.59–3.75%
	3.25 < F3 < = 3.5	0.35%	0.35–0.35%	0.68%	0.65–0.72%
Criteria 5	F4 > 4.12	0.71%	0.71–0.71%	2.52%	2.45–2.59%
	3.25 < F3 < = 4.12	0.84%	0.84–0.85%	1.83%	1.77–1.89%
		One Metabolic Co-Morbidity		Two Metabolic Co-Morbidities
		N = 231,429		N = 208,943
	FIB-4 Categories	Prevalence (%)	95% CI	Prevalence (%)	95% CI
Criteria 1	F3/F4 > 2.67	5.07%	4.98–5.16%	4.79%	4.70–4.88%
Criteria 2	F4 > 4.12	1.70%	1.64–1.75%	1.46%	1.41–1.51%
	2.67 < F3 < = 4.12	3.37%	3.30–3.44%	3.33%	3.25–3.41%
Criteria 3	F4 > 3.5	2.56%	2.50–2.63%	2.29%	2.23–2.36%
	2.67 < F3 < = 3.5	2.51%	2.44–2.57%	2.50%	2.43–2.57%
Criteria 4	F4 > 3.5	2.56%	2.50–2.63%	2.29%	2.23–2.36%
	3.25 < F3 < = 3.5	0.51%	0.48–0.54%	0.53%	0.49–0.56%
Criteria 5	F4 > 4.12	1.70%	1.64–1.75%	1.46%	1.41–1.51%
	3.25 < F3 < = 4.12	1.38%	1.33–1.43%	1.35%	1.30–1.40%
		Three Metabolic Co-Morbidities		Four Metabolic Co-Morbidities
		N = 117,797		N = 43,035
	FIB-4 Categories	Prevalence (%)	95% CI	Prevalence (%)	95% CI
Criteria 1	F3/F4 > 2.67	5.57%	5.44–5.70%	6.68%	6.44–6.92%
Criteria 2	F4 > 4.12	1.53%	1.46–1.60%	1.62%	1.50–1.74%
	2.67 < F3 < = 4.12	4.04%	3.93–4.15%	5.06%	4.86–5.27%
Criteria 3	F4 > 3.5	2.47%	2.38–2.56%	2.81%	2.66–2.97%
	2.67 < F3 < = 3.5	3.10%	3.00–3.20%	3.87%	3.69–4.05%
Criteria 4	F4 > 3.5	2.47%	2.38–2.56%	2.81%	2.66–2.97%
	3.25 < F3 < = 3.5	0.59%	0.55–0.64%	0.76%	0.68–0.84%
Criteria 5	F4 > 4.12	1.53%	1.46–1.60%	1.62%	1.50–1.74%
	3.25 < F3 < = 4.12	1.53%	1.46–1.60%	1.95%	1.82–2.09%