Table 4. The clinical sensitivity of five diagnostic methods for low infection intensity STH infections.
The Table summarizes the clinical sensitivity and corresponding 95% confidence intervals [95% CI] of Kato-Katz (single and duplicate), Mini-FLOTAC, FECPAKG2 and qPCR across low intensity infections of Ascaris (n = 340), Trichuris (n = 519) and hookworms (n = 602). In addition, it reports the level of significance (p-value) for the hypothesis that the clinical sensitivity is different from that of a single Kato-Katz.
| Ascaris (n = 340) | Trichuris (n = 519) | Hookworm (n = 602) | ||||
|---|---|---|---|---|---|---|
| Sensitivity (%) [95% CI] | p-value | Sensitivity (%) [95% CI] | p-value | Sensitivity (%) [95% CI] | p-value | |
| Single Kato-Katz | 55.6 [50.6; 60.9] | 79.6 [76.0; 82.9] | 69.4 [65.8; 73.1] | |||
| qPCR | 86.2 [82.4; 89.7] | <0.001 | 91.0 [88.5; 93.5] | <0.001 | 91.0 [88.7; 93.2] | <0.001 |
| Duplicate Kato-Katz | 57.4 [52.4.1; 62.6] | 0.978 | 84.4 [81.2; 87.5] | 0.060 | 72.4 [68.9; 75.9] | 0.512 |
| Mini-FLOTAC | 42.1 [36.8; 47.4] | <0.001 | 85.6 [82.5; 88.5] | 0.013 | 70.8 [66.9; 74.3] | 0.952 |
| FECPAKG2 | 36.8 [31.8; 42.1] | <0.001 | 37.5 [33.3; 41.7] | <0.001 | 47.5 [43.5; 51.5] | <0.001 |